1. A. Espona, F. Tampieri, C. Canal. Engineering alginate-based injectable hydrogels combined with bioactive polymers for targeted plasma-derived oxidative stress delivery in osteosarcoma therapy. International Journal of Biological Macromolecules, Volume 257, Part 2, 2024, 128841. doi:  OPEN ACCESS.



      1. M. Živanić, A. Espona-Noguera, H. Verswyvel, E. Smits, A. Bogaerts, A. Lin, C. Canal. Injectable Plasma-Treated Alginate Hydrogel for Oxidative Stress Delivery to Induce Immunogenic Cell Death in Osteosarcoma. Adv. Funct. Mater. 2023, 2312005. doi: OPEN ACCESS..

      2. M. Živanić, A. Espona-Noguera, A. Lin C. Canal. Current State of Cold Atmospheric Plasma and Cancer-Immunity Cycle: Therapeutic Relevance and Overcoming Clinical Limitations Using Hydrogels. Adv. Sci.2023, 2205803. doi: OPEN ACCESS.

      3. J. Tornín, M. Mateu-Sanz, V. Rey, D. Murillo, C. Huergo, B. Gallego, A. Rodriguez, R. Rodríguez, C. Canal. Cold plasma and inhibition of STAT3 selectively target tumorigenicity in osteosarcoma. Redox Biology, Volume 62, June 2023, 102685. doi: // OPEN ACCESS.

      4. J. Tornín, B. Gallego, V. Rey, D. Murillo, C. Huergo, A. Rodríguez, C. Canal, R. Rodríguez. Cold plasma-treated medium preferentially eliminates doxorubicin-resistant osteosarcoma cells. Free Radical Biology and Medicine. Volume 209, Part 1, 20 November 2023, Pages 127-134. doi: OPEN ACCESS.

      5. F. Tampieri, A. Espona-Noguera, C. Labay, M.-P. Ginebra, M. Yusupov, A. Bogaerts, C. Canal. Does non-thermal plasma modify biopolymers in solution? A chemical and mechanistic study for alginate. Biomater. Sci. April 2023. doi:

      6. X. Solé-Martí, C. Labay, Y. Raymond, J. Franch, R. Benitez, M.P. Ginebra, C. Canal. Ceramic-hydrogel composite as carrier for cold-plasma reactive-species: Safety and osteogenic capacity in vivo. Plasma Process Polym. Volume 20, Issue 1, Jan 2023. doi: // OPEN ACCESS.

      7. F. Tampieri, Y. Gorbanev, E. Sardella. Plasma‐treated liquids in medicine: Let's get chemical. Plasma Process Polym. 2023;e2300077. doi: OPEN ACCESS.

      8. C. Bucci, F. Tampieri, M.Mateu-Sanz, R. Laurita, V. Colombo, C. Canal. Oxidation of lactate to pyruvate mediates the cytotoxic potential of physical plasma-treated saline solutions in ovarian cancer. Plasma Process. Polym., e2300093. doi: 10.1002/ppap.202300093. OPEN ACCESS.

      9. C. Canal, A. Espona-Noguera, F. Tampieri. Special issue: Plasma Medicine - part I. Plasma Process. Polym., Vol 20, September 2023, e2370019. doi: 10.1002/ppap.202370019. Editorial and Front Cover. OPEN ACCESS.

      10. Canal, A. Espona-Noguera, F. Tampieri (2023). Interdisciplinarity: In the DNA of plasma medicine. Special issue: Plasma Medicine - part II. Plasma Process. Polym., 20, e2377001. doi: 10.1002/ppap.202377001. Editorial and Front Cover. OPEN ACCESS.



      1. A. Przekora, L. Penolazzi, G. Kalisz, P. Kazimierczak, C. Canal, M. Wojcik, R. Piva, A. Sroka-Bartnicka. Osteoclast-mediated acidic hydrolysis of thermally gelled curdlan component of the bone scaffolds: Is it possible? Carbohydrate Polymers, Volume 295, 2022, 119914. doi: OPEN ACCESS.

      2. Y. Raymond, C. Lehmann, E. Thorel, R. Benitez, A. Riveiro, J. Pou, M.C. Manzanares, J. Franch, C. Canal, M.P. Ginebra. 3D printing with star-shaped strands: A new approach to enhance in vivo bone regeneration. Biomaterials Advances, Volume 137 (2022) 212807. doi :// OPEN ACCESS.

      3. A. Michalicha. A. Espona-Noguera, C. Canal, B. Budzyńska, M. Pięt, S. Przywara, J. Pawelec, A. Belcarz. Polycatecholamine and gentamicin as modifiers for antibacterial and blood-biocompatible polyester vascular prostheses. Materials Science and Engineering: C. 2022, 112645. doi:

      4. M. Mateu-Sanz, M.P. Ginebra, J. Tornín, C. Canal. Cold atmospheric plasma enhances doxorubicin selectivity in metastasic bone cáncer. Free Radical Biology and Medicine 189 (2022) 32–41. doi: OPEN ACCESS.
      5. X. Solé-Martí, T. Vilella, C. Labay, F. Tampieri, M.P. Ginebra, C. Canal. Thermosensitive hydrogels to deliver reactive species generated by cold atmospheric plasma: a case study with methylcellulose. Biomater. Sci., 2022, Advance Article. doi: OPEN ACCESS.

      6. A. Michalicha, C. Canal, A. Espona-Noguera, M. Piet, B. Budzyńska, S. Przywara, A. Belcarz. Collagen-Sealed Polyester Vascular Prostheses Functionalized by Polycatecholamine Coatings. International Journal of Molecular Sciences. 2022; 23(16):9369. doi://

      7. F. Tampieri, A. G. Araguz, C. Canal. Can we remove tattoos with non‐thermal atmospheric plasma? Plasma Process Polym. 2022;e2100188. doi: 10.1002/ppap.202100188. OPEN ACCESS.

      8. I Adamovich, S Agarwal, E Ahedo, L L Alves, S Baalrud, N Babaeva, A Bogaerts, A Bourdon, P J Bruggeman, C Canal, E H Choi, S Coulombe, Z Donkó, D B Graves, S Hamaguchi, D Hegemann, M Hori, H-H Kim, G M W Kroesen, M J Kushner, A Laricchiuta, X Li, T E Magin, S Mededovic Thagard, V Miller, A B Murphy, G S Oehrlein, N Puac, R M Sankaran, S Samukawa, M Shiratani, M Šimek, N Tarasenko, K Terashima, E Thomas Jr, J Trieschmann, S Tsikata, M M Turner, I J van der Walt, M C M van de Sanden, T von Woedtke. The 2022 Plasma Roadmap: low temperature plasma science and technology. J. Phys. D: Appl. Phys. 55 (2022) 373001. doi:// OPEN ACCESS.



      1. J. Tornin, C. Labay, F. Tampieri, M.P. Ginebra, C. Canal. Evaluation of the effects of cold atmospheric plasma and plasma-treated liquids in cancer cell cultures. Nature Protocols volume 16, pages2826–2850 (2021). doi: OPEN ACCESS.

      2. M.Á. Brennan, D.S. Monahan, B. Brulin, S. Gallinetti, P. lHumbert, Ch. Tringides, C. Canal, M.P. Ginebra, P. Layrolle. Biomimetic versus sintered macroporous calcium phosphate scaffolds enhanced bone regeneration and human mesenchymal stromal cell engraftment in calvarial defects. Acta Biomaterialia Volume 135, November 2021, Pages 689-704. doi:

      3. Y. Raymond, M. Bonany, C. Lehmann, E. Thorel, R. Benítez, J. Franch, M. Espanol, X. Solé-Martí, M.C. Manzanares, C. Canal, M.P. Ginebra. Hydrothermal processing of 3D-printed calcium phosphate scaffolds enhances bone formation in vivo: a comparison with biomimetic treatment. Acta Biomaterialia Volume 135, November 2021, Pages 671-688. doi: OPEN ACCESS.

      4. O. Estupiñán, E. Niza, I. Bravo, V. Rey, J. Tornín, B. Gallego, P. Clemente-Casares, F. Moris, A. Ocaña, V. Blanco-Lorenzo, M.Rodríguez-Santamaría , A. Vallina-Álvarez, M.V. González, A. Rodríguez, D. Hermida-Merino, C. Alonso-Moreno,R. Rodríguez. Mithramycin delivery systems to develop effective therapies in sarcomas. Journal of Nanobiotechnology. 2021 Sep 6;19(1):267. doi: 10.1186/s12951-021-01008-x. OPEN ACCESS.

      5. J. Tornín, A. Villasante, X. Solé-Martí, M.P. Ginebra, C. Canal. Osteosarcoma tissue-engineered model challenges oxidative stress therapy revealing promoted cancer stem cell properties. Free Radical Biology and Medicine 164 (2021) 107–118. doi: OPEN ACCESS.

      6. F. Tampieri, M.P. Ginebra, C. Canal. Quantification of Plasma-Produced Hydroxyl Radicals in Solution and their Dependence on the pH. Anal. Chem., 2021. DOI: 10.1021/acs.analchem.0c04906.  OPEN ACCESS.

      7. X. Solé-Martí, A. Espona-Noguera, M.P Ginebra, C. Canal. Plasma-Conditioned Liquids as Anticancer Therapies In Vivo: Current State and Future Directions. Cancers 2021, 13(3), 452; doi:  OPEN ACCESS.

      8. B. Tarabová, F. Tampieri, E. Maran, E. Marotta, A. Ostrihoňová, M. Krewing, Z. Machala. Chemical and Antimicrobial Effects of Air Non-Thermal Plasma Processing of Fresh Apple Juice with Focus on Safety Aspects. Foods. 2021; 10(9):2055. doi: // OPEN ACCESS.

      9. I. Hamouda, C. Labay, U. Cvelbar, MP. Ginebra, C. Canal. Selectivity of direct plasma treatment and plasma‑conditioned media in bone cancer cell lines. Scientific Reports (2021) 11:17521. doi: OPEN ACCESS.

      10. M. Mateu-Sanz, J. Tornín, M.P. Ginebra, C. Canal. Cold Atmospheric Plasma: A New Strategy Based Primarily on Oxidative Stress for Osteosarcoma Therapy. J. Clin. Med. 2021, 10, 893. doi: OPEN ACCESS.

      11. D. Boehm, C. Canal. Application of Plasma Technology in Bioscience and Biomedicine. Appl. Sci. 2021, 11(16), 7203; OPEN ACCESS.

      12. J. Buxadera-Palomero, K. Fricke, S. Reuter, F.J. Gil, D. Rodriguez, C. Canal. One-Step Liquid Phase Polymerization of HEMA by Atmospheric-Pressure Plasma Discharges for Ti Dental Implants. Appl. Sci. 2021, 11, 662. doi:  OPEN ACCESS.

      13. R. Schieber, Y. Raymond, C. Caparrós, J. Bou, E. Herrero Acero, G.M. Guebitz, C. Canal, M. Pegueroles. Functionalization Strategies and Fabrication of Solvent-Cast PLLA for Bioresorbable Stents. Appl. Sci. 2021, 11, 1478. doi: OPEN ACCESS.



      1. C. Labay, M. Roldán, F. Tampieri, A. Stancampiano, P. Escot Bocanegra, M.-P. Ginebra, C. Canal, Enhanced Generation of Reactive Species by Cold Plasma in Gelatin Solutions for Selective Cancer Cell Death, ACS Appl. Mater. Interfaces, 2020, 12, 42, 47256–47269. doi: 

      2. P. Kazimierczak, A. Benko, K. Palka, C. Canal, D. Kolodynska, A. Przekora. Novel synthesis method combining a foaming agent with freeze-drying to obtain hybrid highly macroporous bone scaffolds. Journal of Materials Science & Technology, Volume 43, 15 April 2020, Pages 52-63. doi: 

      3. M. Mateu-Sanz, J Tornín, B. Brulin, A. Khlyustova, M.P. Ginebra , P. Layrolle, C. Canal. Cold Plasma-Treated Ringer's Saline: A Weapon to Target Osteosarcoma, Cancers 2020, Vol. 12, Page 227, vol. 12, no. 1, p. 227 doi: 10.3390/cancers12010227. OPEN ACCESS.

      4. A. Przekora, M. Audemar, J. Pawlat, C, Canal, J.S. Thomann, C. Labay, M. Wojcik, M. Kwiatkowski, P. Terebun, G. Ginalska, S. Hermans, D. Duday. Positive Effect of Cold Atmospheric Nitrogen Plasma on the Behavior of Mesenchymal Stem Cells Cultured on a Bone Scaffold Containing Iron Oxide-Loaded Silica Nanoparticles Catalyst. Int. J. Mol. Sci. 2020, 21, 4738; doi:10.3390/ijms21134738. OPEN ACCESS.

      5. I. Hamouda, C.Labay, M.P. Ginebra, E. Nicol, C. Canal. Investigating the atmospheric pressure plasma jet modification of a photo-crosslinkable hydrogel, Polymer, Volume 192, 27 March 2020, 122308. doi: OPEN ACCESS.



      1. M. Godoy-Gallardo, C. Labay, L. Hosta-Rigau. Tyrosinase-Loaded Multicompartment Microreactor toward Melanoma Depletion. ACS Appl. Mater. Interfaces, 2019, 11 (6), pp 5862–5876. doi: 10.1021/acsami.8b20275

      2. J. Tornin, M. Mateu-Sanz, A. Rodríguez, C. Labay, R. Rodríguez, C. Canal. Pyruvate Plays a Main Role in the Antitumoral Selectivity of Cold Atmospheric Plasma in Osteosarcoma. Scientific Reports, volume 9, Article number: 10681 (2019). doi: OPEN ACCESS.

      3. C. Labay, I. Hamouda, F. Tampieri, M.P. Ginebra, C. Canal. Production of reactive species in alginate hydrogels for cold atmospheric plasma-based therapies. Scientific Reports, 9, 16160 (2019). doi: OPEN ACCESS.

      4. A. Khlyustova, C. Labay, Z. Machala, M.P. Ginebra, C.Canal. Important parameters in plasma jets for the production of RONS in liquids for plasma medicine: a brief review. Frontiers of Chemical Science and Engineering. Doi:

      5. A. Przekora, J. Pawlat, P. Terebun, D. Duday, C. Canal, S. Hermans, M. Audemar, C. Labay, J.-S. Thomann, G. Ginalska, The effect of low temperature atmospheric nitrogen plasma on MC3T3-E1 preosteoblast proliferation and differentiation in vitro. Journal of Physics D: Applied Physics (2019) 52: 275401. doi: OPEN ACCESS.

      6. U. Cvelbar, J.L. Walsh, M. Černák, H.W. de Vries, S. Reuter, Th. Belmonte, C. Corbella, C. Miron, N. Hojnik, A. Jurov, H. Puliyalil, M. Gorjanc, S. Portal, R. Laurita, V. Colombo, J. Schäfer, A. Nikiforov, M. Modic, O. Kylian, M. Polak, C. Labay, J.M. Canal, C. Canal, M. Gherardi, K. Bazaka, P. Sonar, K.K. Ostrikov, D. Cameron, S. Thomas, K.D. Weltmann. White paper on the future of plasma science and technology in plastics and textiles. Plasma Process Polym.2019;16:e1700228. doi: 10.1002/ppap.201700228



      1. G. Mestres, M.A. Fernandez-Yague, D. Pastorino, E.B. Montufar, C. Canal, M.C. Manzanares-Céspedes, M.P. Ginebra. In vivo efficiency of antimicrobial inorganic bone grafts in osteomyelitis treatments. Materials Science & Engineering C 97 (2019) 84–95. doi: ISSN: 0928-4931. Impact Factor: 5.080. Q1 6/33 Materials Science, Biomaterials. 

      2. K. Khurana, F. Müller, K. Jacobs, Th. Faidt, J-U. Neurohr, S. Grandthyll, F. Mücklich, C. Canal, M.P. Ginebra. Plasma polymerized bioceramics for drug delivery: Do surface changes alter biological behaviour? European Polymer Journal 107 (2018) 25–33. doi:

      3. C. Lo Porto, F. Palumbo, J. Buxadera-Palomero, C, Canal, P. Jelinek, L. Zajickova, P. Favia. On the plasma deposition of vancomycin-containing nano-capsules for drug-delivery applications. Plasma Process Polym. 2018;e1700232. doi:



      1. C. Canal, R. Fontelo, I. Hamouda, J. Guillem-Martí, U. Cvelbar, M.P. Ginebra. Plasma-induced selectivity in bone cancer cells death. Free Radical Biology and Medicine 110 (2017) 72-80. doi:

      2. J. Buxadera-Palomero, C. Calvo, S. Torrent-Camarero, F.J. Gil, C. Mas-Moruno, C. Canal, D. Rodríguez. Biofunctional polyethylene glycol coatings on titanium: An in vitro-based comparison of functionalization methods. Colloids Surf B Biointerfaces. 2017 Jan 24;152:367-375. doi: 10.1016/j.colsurfb.2017.01.042.

      3. S. Gallinetti, G. Mestres, C. Canal, C. Persson, M.P. Ginebra. A novel strategy to enhance interfacial adhesion in fiber-reinforced calcium phosphate cement. Journal of Mechanical Behaviour of Biomedical Materials 75 (2017) :495-503. doi: 10.1016/j.jmbbm.2017.08.017.

      4. U. Cvelbar, C. Canal, M. Hori. Editorial: Plasma-inspired biomaterials. J. Phys. D: Appl. Phys. 50 (2017) 040201 (4pp) doi:10.1088/1361-6463/50/4/040201. OPEN ACCESS.



      1. C. Canal, M. Modic, U. Cvelbarc, M.P. Ginebra. Regulating the antibiotic drug release from β-tricalcium phosphate ceramics by atmospheric plasma surface engineering. Biomater. Sci., 2016, 4, 1454. doi: 10.1039/c6bm00411c

      2. C. Canal, K. Khurana, S. Gallinetti, S. Bhatt, J. Pulpytel, F Arefi-Khonsari, M.P. Ginebra. Design of Calcium Phosphate Scaffolds with controlled Simvastatin release by Plasma polymerization. Polymer, v.92, 2016, pp.170-178. doi: 10.1016/j.polymer. 2016.03.069

      3. C. Labay, J. Buxadera-Palomero, M. Avilés, C. Canal, M.P. Ginebra. Modulation of release kinetics by plasma polymerization of ampicillin-loaded β-TCP ceramics. J. Phys. D: Appl. Phys. 49 (2016) 304004 (10pp). doi:10.1088/0022-3727/49/30/304004



      1. C. Labay, J.M. Canal, M. Modic, U. Cvelbar, M. Quiles, M. Armengol, M.A. Arbos, F.J. Gil, C. Canal. Antibiotic-loaded polypropylene surgical meshes with suitable biological behaviour by plasma functionalization and polymerization. Biomaterials 71 (2015) 132- doi: 10.1016/j.biomaterials.2015.08.023.144

      2. D. Pastorino, C. Canal, M.P. Ginebra. Multiple characterization study on porosity and pore structure of calcium phosphate cements. Acta Biomaterialia (2015) 205-214, doi: 10.1016/j.actbio.2015.09.017

      3. D. Pastorino, C. Canal, M.P. Ginebra. Drug delivery from injectable calcium phosphate foams by tailoring the macroporosity-drug interaction. Acta Biomaterialia 12 (2015):250-9. doi: 10.1016/j.actbio.2014.10.031

      4. J. Buxadera-Palomero, C. Canal, S. Torrent-Camarero, B. Garrido, F.J. Gil, D. Rodríguez. Antifouling coatings for dental implants: Polyethylene glycol-like coatings on titanium by plasma polymerization. Biointerphases (2015); 10(2):029505. doi: 10.1116/1.4913376

For full papers, please go to FUTUR (UPC) database.